2013 BioArt Video clip Winners – Amanda L. Zacharias*† and John I. Murray*


College of Pennsylvania Perelman Faculty of Medicine, Philadelphia, PA

This time-lapse movie shows the progress of a microscopic worm (Caenorhabditis elegans) embryo from the one cell stage to hatching. The nuclei are tagged with a inexperienced fluorescent marker and an vital genetic regulation molecule involved in afterwards embryonic progress seems in red. The worm C. elegans develops with an invariant lineage, which usually means the cells divide in the exact buy and posture in each and every embryo. This exclusive house enabled the Nobel Prize-successful discovery of programmed cell dying. Scientists also benefit from the invariant lineage to assess the expression of vital developmental genes, numerous of which are conserved between people and nematodes, in standard and mutant C. elegans embryos. Zacharias and Murray’s exploration is supported by the NIH Eunice Kennedy Shriver Nationwide Institute of Youngster Wellbeing and Human Enhancement and Nationwide Institute of Basic Clinical Sciences.

* Genetics Society of The united states
† Society for Developmental Biology
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